Huge old electricity plant near Ostbahnhof with industrial-style Panoramabar (Fridays, usually only Panorama open), world famous techno dance club (open only Saturday nights along with Panorama) and Lab-Oratory (special location for play and cruise parties, mostly open seperate during the week, men only). Also live performances. One of Berlin's hotspots on Friday, Saturday and Sunday night.
Easy to get to with S-Bahn - take the train to Ostbahnhof, take the main exit keeping McDonalds on your left, turn left as you walk out of the station, walk down a bit and take the first right following the train line now on your right side, take the first left and keep walking with a chain fence on your right - now join the end of the queue because there is always one. Expect 1-2 hour wait.
Attention: Take a taxi if you are not familiar.